Bub3’s function doesn’t stop at the checkpoint
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چکیده
منابع مشابه
Bub3’s function doesn’t stop at the checkpoint
Fewer forks make faster progress J ust as a large number of forks can inhibit someone unaccustomed to formal dining, an excess of replication forks can slow the rate of DNA synthesis, Zhong et al. reveal. Cdc7 is the catalytic subunit of the Dbf4-dependent kinase, which initiates DNA replication by activating the DNA helicase complex MCM at replication origins. In response to DNA damage, the ch...
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The cyclin-dependent kinases (CDKs) must be inhibited when DNA damage occurs to prevent cell-cycle progression and to allow for repair. A paper in the June issue of EMBO reports from Rene Medema’s group now suggests that some CDK activity must actually be retained during arrest for efficient checkpoint recovery to occur (Alvarez-Fernández et al, 2010). Cells have evolved several mechanisms to e...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2013
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.2013iti2